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Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice

The amount of NAPQI produced differs in certain populations

When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)

doi: 10.1111/tid.12454 347 UllmannAJAguadoJMArikan-AkdagliSDenningDWGrollAHLagrouKet al