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Treatment effect appears to be clinically evident starting from one to three months after treatment completion, with a subsequent progressive decrease of the achieved EF benefit over time, although some effects could be still detected up to five years after treatment [490,492,498]

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Thus, female C/EBP uORF mice gain less fat upon aging similar to mice under CR or upon prolonged rapamycin treatment (Fang et al., 2013) ( figure supplement 4C ), which probably contributes to an improved health state upon aging and to the extension in lifespan