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To view a copy of this licence, visit About this article Cite this article Jadhav, D., Saraswat, N., Vyawahare, N

Strategies aimed at restoring tryptophan availability in the tumor microenvironment or inhibiting the immunosuppressive effects of tryptophan metabolites hold great promise for enhancing T cell-mediated antitumor immunity and improving checkpoint immunotherapy

That being said, its important to keep in mind that the 4Rs is a general framework - this process needs to be personalized for each individual for the most targeted, effective, and well tolerated approach