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Description

RSL3 contains a reactive chloroacetamide moiety that makes it a potent and irreversible GPX4 inhibitor, although its poor solubility and poor absorption, distribution, metabolism, and excretion (ADME) properties limit its effectiveness in in-vivo studies [22]

Nature 399:362366 Hu Q, DAmora DR, MacNeil LT, Walhout AJM, Kubiseski TJ (2018) The Caenorhabditis elegans oxidative stress response requires the NHR-49 transcription factor

(World Health Organization Press, Geneva, 2005)

Stress response proteins thus play a crucial role in HSCs maintenance and recent studies have underpinned the role of antioxidants, such as tempol and N-acetyl cysteine in maintaining the quiescence of HSCs [20]