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Research indicates that humans are indiscriminate carotenoid accumulators, though it isnt yet clear why.33 Carotenoids may also act as prooxidants by speeding up the radical chain reaction of lipid peroxidation when they react with oxygen radicals or lipid radicals under specified conditions.33 Endogenous Antioxidant Supplements Understanding the risks, including, but not limited to, promotion of prooxidant activity, with high-dose micronutrient and/or phytonutrient dosage, it may be wise to take a food first approach to supporting exogenous antioxidant status, skipping the high-dose supplements

Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes