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Systematic meta-analyses have demonstrated that depression patients have significantly elevated serum IL-6, TNF-, and C-reactive protein (CRP) levels (Osimo et al., 2020)

Meanwhile, correlation analysis between MANF level and clinical variables in ICC showed that high expression of MANF was associated with larger tumor diameter ( P = 0.026), TNM stage ( P = 0.000), and distant metastasis ( P = 0.017) (Supplementary Table 1)