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The addition of GSH or expression of Grxs 1 and 2 significantly improves mutant SOD1 solubility in cell culture, whereas reducing the levels of intracellular GSH decreases SOD1 solubility, suggesting that GSH reduction promotes the aggregation of mutant SOD1 (Guareschi et al., 2012)

One of the inhibitors of the PI3K pathway is the enzyme phosphatase and tensing homolog deleted on chromosome 10 (PTEN)

However, more recently, GSNO has begun to be used as it is considered to be a more physiological NO donor (Liu et al., On the other hand, the involvement of NO in plant reproductive biology has been reported (Bright et al., Lilium longiflorum , Arabidopsis thaliana , and Paulownia tomentosa (Prado et al., Pinus bangeana in a dose-dependent manner (Wang et al., in vitro germination has shown the presence of GSNO (unpublished data) whose content closely correlated with the NO content previously reported (Zafra et al., GSNOR gene expression