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As of yet, this question has been difficult to answer because mechanistic studies of kratom alkaloids have focused largely on isolated alkaloids without consideration of how these alkaloids are represented in kratom materials used medicinally

Hence, by targeting the enzymatic activity of SARM1, inhibitors may effectively prevent the depletion of NAD + , thereby maintaining cellular energy homeostasis and enhancing neuronal resilience, potentially expanding the treatment landscape for various neurological conditions