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As other GSTF members bearing a conserved serine in the active site motif, enzymatic analysis showed that GSTF1 possesses glutathione-conjugating activity toward structurally diverse substrates and glutathione peroxidase activity

Finally, we explored the potential interaction mechanisms between gut microbial metabolites and GPX3 protein through molecular docking and molecular dynamics simulation analyses

A Floel G Garraux B Xu C Breitenstein S Knecht P Herscovitch LG Cohen 2008 Levodopa increases memory encoding and dopamine release in the striatum in the elderly Neurobiol Aging 29 2 267 279 A Muralidharan J Zhang D Ghosh MD Johnson KB Baker JL Vitek 2017 Modulation of neuronal activity in the motor thalamus during GPi-DBS in the MPTP nonhuman primate model of Parkinsons disease Brain Stimul 10 1 126 138 S Menon S Armstrong A Hamzeh NP Visanji SP Sardi A Tandon 2022 Alpha-Synuclein targeting therapeutics for Parkinsons disease and related synucleinopathies Front Neurol 13 852003 Ma YY, Li X, Yu JT, Wang YJ (2024) Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

Of the three amino acids that constitute glutathione, low levels of cysteine compared to a relative abundance of glutamine and glycine often limits your ability to produce the master antioxidant