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CD38 expression in chronic lymphocytic leukemia CD38 is also involved in chronic lymphocytic leukemia (CLL), a malignancy characterized by the accumulation of malignant mature lymphocytes in the peripheral blood, bone marrow and lymphoid tissues [27]

Including clinically diagnosed cases alongside genetically confirmed patients enhances the real-world representativeness of this review but introduces diagnostic heterogeneity and potential misclassification, which may limit the generalizability of treatment-related conclusions, particularly regarding the efficacy of oral vitamin B12 therapy

On the other hand, Cu(I) binds in a linear geometry involving two of the three histidine residues (His6/13/14) in a dynamic exchange 12