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These compounds are known to suppress the expression of pro-inflammatory cytokines such as TNF- and IL-6, predominantly through inhibition of the NF-B pathway

In the rare congenital recessive syndrome of selective malabsorption of folate due to mutation of the proton-coupled folate transporter (PCFT), there is an associated defect of folate transport into the cerebrospinal fluid, and these patients show megaloblastic anemia, which responds to physiologic doses of folic acid given parenterally but not orally

The eyes after infecting toxoplasma gondii showed accumulation of iron in the neurosensory retina, and increased lipid peroxidation, reduction of GPX4 expression and mitochondrial deformity in the photoreceptor, suggesting that ferroptosis plays a crucial role in the induction of retinochoroiditis during ocular toxoplasmosis (Yamada et al., 2023)

10.1371/journal.pone.0146750 256