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Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.J OculPharmacolTher

As discovered more recently by Zhangs group, NRF2 can also be negatively regulated through the E3 ubiquitin-protein ligase synoviolin (HRD1), recently associated with the ER stress produced by misfolded protein accumulation

For example, TNF- suppresses the accumulation of type I collagen within the matrix, while IL-6 enhances overall collagen synthesis (Wang and Li, 2023)