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Acknowledgements The authors would like to acknowledge Kyoto Stock Center, National Institute of Genetics, Vienna Drosophila Resource Center, and Bloomington Drosophila Stock Center for reagents

In this context, PX-12 (1-methylpropyl-2-imidazole disulfide) takes center stage as an irreversible inhibitor of TXN1, showcasing remarkable anti-tumor potential

For instance, in a randomised phase III trial, carboplatin/paclitaxel combination showed clinical benefits but was associated with significant toxicities, including grade 3/4 neutropenia (50%), grade 2 alopecia (86%), neuropathy and hypersensitivity reactions [34]

The disease pathology in MS is largely driven by two principal features: acute inflammation and demyelination