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For example, while FGF21 stimulates sympathetic activation in mice, elevations in cortisol that would suggest hypothalamic-pituitary-adrenal activation have not been observed in monkeys (239)

48 Furthermore, different subsets of macrophages present distinct metabolic functions

When activated by stress-induced hormonal imbalances, these pathways promote the production of pro-inflammatory cytokines and genes associated with oxidative stress, increasing the overall oxidative burden on cells (53)