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It is possible that the processing of vitamin C causes it to become unstable, which may explain why there is evidence that co-supplementation is not more advantageous

10.1021/jm800993r J

The latter mixture was shaken vigorously and after 5 min 10 mL of 70%Na 2 CO 3 w/v was added and diluted immediately to 25 mL by adding distilled water

In reference to a protein, a "substitution variant" is one in which at least one amino acid residue in the native or reference sequence is removed and a different amino acid is inserted at the same position