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Previous evidence has shown that adenosine is one of the neuromodulators involved in the pathophysiology of migraine (218)

It is affecting millions of people, degrading quality of life, and straining a healthcare system that was not designed to address multi-system chronic illness rooted in overlapping biological dysfunctions

The majority involve the lateral ligament complex, particularly the anterior talofibular ligament (ATFL), which sustains damage in approximately 85% of inversion injuries

They synthesize the extracellular matrix components, including type II collagen and proteoglycans, that give cartilage its structural integrity and shock-absorbing properties