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Due to the statutory differences explained above, pneumococcal, influenza and COVID-19 vaccines and their administration are paid at 100 of reasonable cost in RHCs and FQHCsthat is, they are paid separately from the FQHC PPS or the RHC All-Inclusive Rate (AIR) methodologywhile hepatitis B vaccines and their administration are paid as part of the FQHCs PPS or the RHC AIR, which means that they are paid through changes to the facilities' capitated rate

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Meanwhile, elevated ROS activates pro-metastatic signaling pathways such as NF-B [263], promoting angiogenesis, extracellular matrix remodeling, inflammatory responses [318, 319], and epithelialmesenchymal transition (EMT) through upregulation of Snail and Twist [320]