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H 2 O 2 induced a 1.73.0 fold increase in NRF2 target gene expression in ATM-wt tumors (n=4), whereas induction was significantly impaired in ATM-null CLLs (n=4) (Figure 1A)

& Leto, T.L

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When large amounts of iron are present in the body, ROS are generated, causing lipid peroxidation, damaging the lipid membranes, and causing cell death [105]