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HDL-NPs downregulated GPX4 mRNA expression, thereby directly inducing ferroptosis, although the underlying mechanisms remain unknown 132

doi:10.1186/s12902-022-01114-3 [18] Frhlich E, Wahl R

FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface