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SB-01 is a synthetic 7-amino-acid peptide in clinical trials that downregulates TGF-beta-1, a growth factor highly expressed in degenerated discs

Compared to ulcerative colitis, in which the AMP system seems to be adequately induced, colonic Crohn's disease is characterized by low HBD1, regulated by peroxisome proliferator-activated receptor gamma (PPAR), and a compromised induction of HBD2 and HBD3 (307, 308)

, , 1 mg 150 mg 50 mg 100 mg .The pharmaceutical composition may also include fillers and/or diluents, for example, to provide properties suitable for pharmaceutical powder blends in manufacture

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