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Weight loss failure on tirzepatide usually traces back to insufficient dose (need to escalate further), caloric intake still exceeding expenditure despite reduced appetite, metabolic adaptation, or underlying medical conditions like hypothyroidism or PCOS that require separate treatment

Benefits Improved tissue perfusion and healing Growth factor up-regulation Promotes tendon and collagen synthesis Accelerates muscle and bone healing Reduces inflammation Heals stomach and intestine ulcers, leaky gut, IBS, gut dysmotility Dosing Subcutaneous or Near Site of Injury 200 mcg 600 mcg Once a day Evening preferred 8 weeks ON

doi: 10.1007/s12274-020-2664-5

Commonly referenced guidance includes: Initial replacement Maintenance For maintenance, the BNF lists adult prophylaxis/maintenance dosing such as 1 mg intramuscularly every 23 months in appropriate cases