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Activation of p53 prevents APAP-induced toxicity in vitro by promoting Nrf2 activation and its downstream target gene expression To further elucidate the protective mechanism of p53 against APAP toxicity, we treated AML12 cells with Dox (125500 nM) and also found a dose-dependent upregulation of mRNA levels of Mrp2/3/4, Nqo1 , and GST/ (Fig

Morphologically, it is mainly characterized by mitochondrial atrophy, increased membrane density and decreased or absent mitochondrial cristae

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