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3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity

Oleic acid exerts direct and indirect suppression of NF-B, a key inflammatory transcription factor, and reduces NLRP3 inflammasome activation, thereby limiting production of pro-inflammatory cytokines IL-1 and IL-18 [70]

Newer treatments are available that provide every 12 to 16-week dosing for some patients in clinical studies, but real-world data show that most patients are falling short of this durability promise

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