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Unlike full-length growth hormone, which is associated with alterations in insulin sensitivity in experimental systems, AOD 9604 demonstrates a distinct signaling profile [2]

High activity of NNMT is also correlated with lower levels of glucose transporter 4 (GLUT4), which is vital for glucose uptake from the bloodstream into fat and muscle cells

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Although the concept of combination synergy is highly dependent on the underlying assumptions (37), according to SynergyFinder 3.0 the synergy scores can be interpreted as follows: from -10 to 10 the interaction is likely to be additive, larger than 10 the interaction is likely to be synergistic, and conversely, if the score in less than -10, then the interaction between the two drugs is most likely antagonistic