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Immune cells dynamically reprogram their metabolic states to support their specific functions, whether its the rapid proliferation of effector cells or the long-term persistence of memory cells ( Mitochondria contain their own multi-copy circular genome (mtDNA), which encodes 13 essential subunits of the OXPHOS system as well as 22 tRNAs and 2 rRNAs required for their translation ( Both HIV infection itself and certain ART drugs can inflict damage on mitochondria