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The nanosensor was constructed by assembling CDs on the surface of AuNPs, forming an impact shell through AuN interactions

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Other compounds Cyanidin-3-O--glucoside (C3G) increases the expression of Gclc in the liver by increasing cAMP levels to activate protein kinase A (PKA) and then increases the phosphorylation of cAMP response element binding protein (CREB) to promote CREB-DNA binding and increase Gclc transcription

Based on the ICH S2 (R1) guidance document (International Council for Harmonisation, 2011) and White et al.(2020) relevant cytotoxicity was postulated at a minimum of 50% reduction in viability, as compared to the respective vehicle control