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( 3.1.6 Role of NADPH oxidase in ferroptosis NOX, a widely distributed membrane protein in humans, represents the only enzyme capable of directly catalyzing ROS generation ( 3.1.7 Voltage-dependent anion channels in ferroptosis and oxidative stress Voltage-dependent anion channels (VDACs), membrane pore proteins located in the outer mitochondrial membrane, facilitate ion and metabolite transport in eukaryotic cells ( 3.2 Ferroptosis and lipid peroxidation 3.2.1 Definition and mechanism of lipid peroxidation Lipid peroxidation represents a process triggered by excess ROS, involving oxidative generation of polyunsaturated fatty acid phospholipids (PUFA-PE)