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Our analysis revealed that SORD-deficient cells lost the typical filamentous and interconnected mitochondrial network characteristic of fibroblasts ( Figure 1D )

Innate immunity, where macrophages, neutrophils, natural killer cells (NKC) and dendritic cells are gatekeepers, is regulated by chemical-messengers or cytokines and by activation of inflammatory and acute phase responses [108]

The relative resistance of albumin to reduction by DTT upon treatment with auranofin suggested that the ER environment was more reducing, whereas treatment with 2-AAPA made it more oxidizing (Figure 5B)