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In rare cases, taking very high doses of vitamin B12 can cause headaches, stomach issues, and weakness

Medications that can interfere with B 12 absorption Proton pump inhibitors, such as omeprazole/Prilosec) and lansoprazole/Prevacid commonly prescribed medications for heartburn, reflux, or ulcers Histamine H2 receptor antagonists, such as cimetidine (Tagamet), famotidine (Pepcid), and ranitidine (Zantac) also prescribed for heartburn, reflux, or ulcers Metformin, a medication for diabetes National Institutes of Health, Office of Dietary Supplements Robert H

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