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Controlled human trials specifically evaluating AOD-9604 for joint pain and osteoarthritis are needed to establish the level of efficacy and optimal treatment protocols

iii) High risk: Three or more criteria rated as unclear or at least two criteria not met

doi:10.1093/qjmed/hct051

Nicotinamide N-methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine (SAH)