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Discussion Although many antidepressants with different mechanisms are being used, a number of patients have not achieved appropriate therapeutic effects

doi: 10.3174/ajnr.A3785

49 Moreover, administration of high doses of IL-1 fails to exacerbate APAP-induced liver injury, further suggesting a limited role of IL-1 signaling in the pathogenesis of APAP hepatotoxicity

Phase I metabolism is characterized by functionalization of the drug via one or more of the reactions: Oxidation (electron removal, dehydrogenation, or oxygenation) Reduction (electron addition, hydrogenation, or removal of oxygen) Hydration/dehydration (hydrolysis, and addition or removal of water) These transformations are carried out in the endoplasmic reticulum of hepatocytes and the most prominent Phase I reactions are oxidations