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Recently HO-1 has been demonstrated to play a significant role in lipid peroxidation during ferroptosis

Under normal circumstances, sows have their own antioxidant defense mechanism, which is mainly composed of antioxidant enzymes (SOD, CAT, GSH, and GSH-Px) and nonenzymatic antioxidants (vitamins, enzyme constituents, etc.,) ( As is well-known, catalase functions by metabolizing hydrogen peroxide into water and oxygen to prevent cellular oxidative damage, including oxidative damage to intracellular macromolecules such as lipid peroxidation

Our findings further contribute to the development of an integrated strategy for improving the early-life intestinal environment that combines conventional pre/probiotics with certain dietary factors that activates Paneth cell function

2011;342:d1542