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In addition, growth factor cell protection, such as with the trophic factor erythropoietin (EPO) (114, 304, 385, 481484), requires decreases in autophagy activation in conjunction with modulation of mTOR, protein kinase B (Akt), the proline rich Akt substrate 40 kDa (PRAS40), and mammalian forkhead transcription factors to promote neuronal and vascular survival (145, 485489)

Moreover, the thickness and consistency of pDA layers were highly sensitive to environmental factors such as dopamine concentration, pH, and temperature, necessitating careful process control ( Phase III consists of multifunctional hybridized coatings (2021present) that facilitate intelligent response and synergistic therapy

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