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Description

Alternatively, the spatial and temporal differences may suggest a sequential response where early changes in the medulla precede and signal subsequential metabolic adaptations in the cortex

The biology is unusual

Clinically validated biomarkers of OS, such as F2-isoprostanes (which indicate lipid peroxidation), 8-OHdG (which indicates DNA damage), and the activities of redox enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), show strong correlations with disease progression and end-organ complications