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RSC Adv 12(8):47144759

Maasumi K, Tepper SJ, Kriegler JS

However, the hepatic extraction ratio for morphine is morphine clearance (60 L/h/70 kg) divided by hepatic blood flow (90 L/h/70 kg) or 0.67

If caffeine consistently causes anxiety, jitteriness, or interferes with sleep, consider reducing your intake or switching to lower-caffeine alternatives such as green tea