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Description

10.1021/jf0116698 215 SukumariRameshS.BentleyJ

Tor/mTOR is a serine/threonine kinase with a molecular weight of approximately 289 kDa and is classified within the phosphoinositide 3-kinase-related kinase (PIKK) family owing to structural similarities in its catalytic domain

Interestingly, inhibition of CIA was observed even when ICOSL blocking antibody was given after the onset of disease (114)

It is important to emphasize how this kind of degeneration differs from OHC apoptosis, which features cell shrinkage, membrane blebbing, karyorrhexis, and apoptotic bodies