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Increased incidence of endstage renal failure secondary to diabetes mellitus in Asian ethnic groups in the United Kingdom

FM shows a marked familial aggregation, indicating a genetic predisposition to this disorder

33 Hypomethylation of microRNA-203, for example, downregulates the expression of the FA adhesome, leading to ECM remodeling and increased VSMC stiffness via an altered FAK/Src pathway 33

Treatment effects based on data obtained from treatment completers A frequently used method to estimate the effect in randomized trials is through restricting the analysis set to comprising only data from patients who continue the randomized treatment until the scheduled end-of-treatment visit (i.e., treatment completers)