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HUBERMAN: Why something is doing what it's doing or how it got there

Melanocytes in vitiligo are thought to be damaged by an accumulation of reactive oxygen species to destroy the structural and functional integrity of their DNA, lipids, and proteins

doi: 10.1007/s11306-015-0816-5 188 KennedyGSpenceVAMcLarenMHillAUnderwoodCBelchJJ

Nonetheless, many clinical investigations are limited by short follow-up durations, small sample sizes, heterogeneous formulations, and reliance on surrogate endpoints, such as variations in bacterial diversity or inflammatory markers, rather than definitive clinical outcomes, thereby limiting the robustness of current conclusions (2, 4)