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X., Wu, Q., & Xu, Y

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Alpha-1 Antitrypsin Deficiency (AATD-1) Beam Therapeutics is testing a base editing treatment for alpha-1 antitrypsin deficiency (AATD-1)

2022 Although N isoforms can also act as dominant-negative inhibitors of the full-length proteins and promote tumorigenesis in cells containing wild-type p53 and TAp73 13 in contrast to p53, mice lacking p73 show no increased susceptibility to spontaneous tumorigenesis