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For instance, following acute myocardial infarction, CD8+ T cells are recruited to ischemic heart tissue, where they release granzyme B, which is linked with adverse post-ischemic cardiac remodeling and fibrosis

This elevation in NAD+ activates sirtuin-1 (SIRT1), often referred to as the longevity gene, which plays a vital role in DNA repair, inflammation reduction, and metabolic regulation