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As a hub target, PPARG integrates anti-inflammatory and metabolic regulatory functions, improving vascular remodeling and right ventricular hypertrophy in PAH rats (Ji et al., 2024)

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In Everyone (Men and Women): High blood pressure Type 2 diabetes or insulin resistance Central weight gain (especially around the abdomen) Fatty liver disease (NAFLD) Depression, anxiety, irritability Sleep disturbances and fatigue Osteopenia or osteoporosis Weakened immune function Higher risk of heart disease and stroke The effects can also differ by gender