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The underlying mechanism involves the suppression of the NF-B signaling pathway, which plays a crucial role in inflammation and keratinocyte proliferation associated with PsO

Available at: fda.gov Rosenfeld RG, et al

Several visual system disorders cause functional and structural alterations in RGCs (i.e., DR, glaucoma, demyelinating optic neuritis, and ischemic optic neuritis) (184)

Esculetin improved lipid metabolism in FFA-treated primary hepatocytes by decreasing expression of Srebp1c and increasing expression of Ppar- as well as reducing lipid accumulation