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Description

Front Immunol (2019) 10:2088

The homological resemblance between thyroxine (TH) and particular TH-disrupting chemicals (TH-EDCs), such as PCB metabolites, dioxin (PCDD), and brominated flame retardants, results in binding to the high-affinity TH transport protein, transthyretin TTR, thereby obstructing T4-TTR binding (Miyawaki et al., 2007)

However, care should be taken in applying these findings clinically, especially with the studys limitations: (a) limited number of studies wherein this was further reduced due to the presence of an outlier study