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The Basics of Metabolic DysfunctionAssociated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment JACC Dietary allicin reduces transformation of L carnitine to TMAO through impact on gut microbiota ScienceDirect Unraveling the Formation Mechanisms of Trimethylamine N Oxide and Its Inhibition by Food Ingredients: Toward Cardioprotective Food Development Journal of Agricultural and Food Chemistry Heart failure and trimethylamine Noxide: time to transform a 'gut feeling' in a fact? Crisci 2023 ESC Heart Failure Wiley Online Library

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doi: 10.1038/nchembio.1352

Mikuls TR, Duryee MJ, England BR, Anderson DR, Hearth-Holmes M, Su K, et al

The Likely Reality Both hormones probably matter, but in different ways

In addition to AGEs and AGE adducts, HMGB1 and A can bind RAGEs to activate the NF-B, ERK1/2, p38, JNK, PI3K, Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, leading to neuronal cell death and neurodegeneration 112