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This research was authorized by the Ethics Committee of the First Peoples Hospital of Zhengzhou, and all patients guardians provided informed permission upon admission

2) Nitric oxide (NO) generated by nitric oxide synthase (NOS) disrupts IL-2 signaling via inhibition of JAK-STAT, ERK, and AKT phosphorylation, destabilizing IL-2 and inducing T-cell apoptosis (188191)