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Prolonged continuous intravenous infusion of the dipeptide l-alanine- l-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury

Peptoids are among a class of biochemicals known as biomimetics, or molecules that mimic the behavior of biological molecules

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Second, translational development should focus on dual-functional nanocarriers incorporating A-targeting peptides and RVG29 brain-homing peptides, delivering GPX4 activators or iron chelators with pH/ROS-responsive release to ensure lesion-specific delivery and avoid neurotransmitter synthesis impairment from non-specific iron depletion