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Under physiological condition with low copper levels, these copper-transporting ATPases are located in the trans-Golgi network (TGN), pumping copper from the cytoplasm into the TGN lumen

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Anti-PD-1 therapy remain ineffective in a large number of cancer patients likely due to initial lukewarm response or disappearance of durable responses [6870]

These include the possibility that EXOs might worsen pre-existing problems by carrying hazardous cargo, as well as dangers related to the EXOs source (such as human biologics or disease transmission)