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Met is first metabolized by methionine adenosyltransferase (MAT) to form S-adenosylmethionine (SAMe, which is also abbreviated as AdoMet) (Figure 1)

Wnt5a activats Wnt/PCP pathway, upregulating Ras-related C3 botulinum toxin substrate 1(Rac), which can activate JNK, thus aggravating IR in adipose tissue

238 The second generation of HAPs consists of compounds that have been structurally modified at the C2 and C6 positions on the basis of the first generation

Epithelial cell and lamina propria isolation Single-cell suspensions of small intestinal epithelium and lamina propria were prepared as described previously 69,70