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PPIs work by blocking gastric H + K + -ATPase (EC 3.6.3.10), which is responsible for pumping H + ions from within gastric parietal cells into the gastric lumen, where they react with Cl ions to form hydrochloric acid (22) (Figure 1)

The overdose of vitamin B12 is very rare because its a water-soluble vitamin, which means excess amounts are usually flushed out through urine

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