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It has been demonstrated that NRF2 over-activation may be therapeutically beneficial for ameliorating RA owing to its anti-inflammatory and anti-oxidative activity associated with limiting cytokine production, cartilage-matrix degradation, and bone resorption 63

While the concentration of LCA used in this study was lower, further investigation into its doseresponse relationship is warranted

US20070232692, US20120101154, the therapeutic agents described herein may be formulated with and/or administered with agents that modulate the activity and/or levels of succinate the therapeutic agents described herein may be formulated with and/or administered with agents that modulate the activity and/or levels of TNF alpha receptor, TRADD, NFNB, STAT3, RhoA, FLIP, FADD, bilirubin, transaminases, and/or caspases